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If a CNS depressant or benzodiazepine are necessary in the affected individual by now on an opioid analgesic: Initiate with a lower Preliminary dose of the benzodiazepine or other CNS depressant; titrate determined by clinical reaction.The realm under the curve is 135ng/mL*hr, maximum plasma focus is eleven.5ng/mL, and the perfect time to utmost co